It all depends on which one sings to you most. The 249 carries the Unitas/ETA movement modified to look like the original movement. WR is 3ATM and the crystal is acrylic. The 448 is of course newer and has the Panerai in house movt. The case is thicker as is the case back. The WR is also 10ATM and the crystal is acrylic. Both 249 and 448 are SE. With the 448 is lesser numbers and does not have the stigma of having the OOR hanging over its head. But prices does not reflect this...

The dials are different between the 249 and 448, the minute track on the 448 is closer to the edge of the dial, giving the impression that the hands are shorter. There are other differences...
The 424.... Date or no date? Which one do you like? Ok with the logo? Ok with the gold hands?
My choice? 448... Why? Price. It is cheaper then 249. The 249 being an I series, 2006. It is going to be 8 years old, service will be due, if not already. Add that to the cost....